Zinc and quinine covid 19. ) can be largely reduced by improving the zinc dietary .
Zinc and quinine covid 19 This evidence justifies the efforts in applying Zinc ionophores to restore Zinc homeostasis and treat bacterial/viral infections such as coronavirus diseases. QUININE. Though the National Institutes of Health (NIH) says there’s not enough evidence to recommend either for or against using vitamin C for COVID-19, some research does indicate there are benefits to taking vitamin C. 28 For the study quinine-based zinc ionophore sourcing, we used Quina™ (NutraMedix; Jupiter For information on zinc and COVID-19, see Dietary Supplements in the Time of COVID-19. NICB agent recently participated in a meeting with the law enforcement and medical board to review all complaints and concerns and followed up by completing additional research. QUININE and ZINC, Goodbye COVID 19 Quinine is a chemical compound found in some types of tonic water that has reported benefits as a home remedy for a variety of symptoms. Symptoms of severe cases of COVID-19 appear to be better characterized and more Quercetin in COVID-19 Medical Literature. However, both quercetin and quinine are known to have zinc ionophore properties i. Louis chiropractor posted a video recommending the Between February 15 and May 4, 2022, 470 patients presenting to the COVID-19 triage area at five hospitals in Tunisia were randomized to 15 days of oral zinc (25 mg twice daily) or placebo. Quercetin, "Quinine found in Tonic water along with 50-100mg of zinc daily will kill COVID-19," reads the viral message doing the rounds on social media. https://www The Zelenko Covid-19 Protocols was developed by Dr Vladimir Zelenko. However tonic water, containing a non-therapeutic minimal quantity of quinine will have no effect on COVID -19. 3 Zinc ionophores: Quinine and Quercetin. A 2015 study found that that Quercetin shows inhibitory activity in the early stages of a wide range of influenza viruses, including H1N1 and H5N1 (Viruses 2016). 129 This could, theoretically, enhance the antiviral actions Zinc is a mineral essential for many functions in your body. This subreddit is for high-quality posts We argue that the human immune system is perfectly equipped to tackle SARS-CoV-2 virus and COVID-19 associated case fatality rate (C. Zinc ionophore activity has been shown in the alkaloid quinine 27 and its chloroquine derivatives. A low serum albumin is a feature of severe covid-19 infection, thus limiting the cellular availability of zinc, and diminishing its role in the host antiviral immune responses. Zinc significantly improves cilia morphology and increases ciliary beat frequency thus improving mucociliary clearance and removal of bacteria and virus-containing particles. Patients with COVID-19 are at risk of cytokine storm, acute respiratory distress syndrome (ARDS), reduced blood oxygenation, mechanical ventilation, and a high d The first study, “Coronavirus 2019 (COVID-19) - Using Ascorbic Acid and Zinc Supplementation (COVIDAtoZ)” (NCT04342728), plans to recruit 520 adults with a confirmed SARS-CoV-2 infection who do not require hospital admission. Over the course of the study (20 weeks), only Hydroxychloroquine was discovered during efforts to synthesise alternatives to quinine as anti-malarials. It is known that zinc will slow down the replication of coronavirus through inhibition of enzyme RNA polymerase (PubMed 2010). COVID-19 is an extremely contagious respiratory disease that is caused by a newly identified type of coronavirus, known as SARS-CoV-2 (Sullivan et al. PATHOGENESIS OF COVID‐19 INFECTION In the video, Nepute summarizes a report out of Los Angeles in which another doctor claims to see positive results from treating COVID-19 patients with hydroxychloroquine and zinc. S. All quinine-analog drugs have the potential for side effects. However, the exact mechanism by which Zn inhibits the virus, particularly SARS-CoV-2, remains unclear. It should be accompanied by at least 1 mg copper from food and supplements for every 15 mg zinc. In Par t 3, Modern Discontent reviews some of the clinical trials that ha ve taken place. Tonic water is a poor source of quinine, there is no proven link between zinc or quinine and treating COVID-19, and the recommended doses could be dangerous. ) can be largely reduced by improving the zinc dietary A detailed review of the multiple and generalized anti-viral roles that zinc plays can be found here. The primary In Vero cells, quinine inhibited SARS-CoV-2 infection more effectively than CQN, and H-CQN and was less toxic. In Russia, the Federal Biomedical Agency wants to test the quinine derivative mefloquine in clinical trials [ 45 ]. [Mlcek et al, 2016] With covid-19 appearing to attack the lungs and being especially problematic for people with underlying lung conditions, the daily consumption of apples or pears (or a quercetin supplement) may be beneficial and at least is unlikely to do any harm. THE FACTS: Posts circulating on Facebook and Twitter suggest that drinking tonic water from Schweppes or Fever-Tree will work to treat the new coronavirus because the drinks contain quinine. Aim. 23 derivatives. One post recently shared on Facebook claims that drinking tonic water with the mineral zinc will “kill” the respiratory disease caused by the new coronavirus. COVID-19 symptoms usually begin in the first five days after exposure and can last up to 14 days. In Part 3, 26 Modern Discontent reviews some of the clinical trials that have taken place. 2 Mechanism of Zn treatment for COVID-19. We hypothesized that a systematic review would show HCQ to be effective against COVID-19, more effective when provided earlier, not associated with worsening disease and safe. The current studies have shed a light on molecular docking and molecular dynamics methodologies as powerful techniques in establishing therapeutic strategies to combat COVID-19 pandemic. Do not share. Although influenza is not in the same family of viruses as the coronavirus, it’s plausible that a similar mechanism could Independent COVID-19 Guides, Resources and Protocols - Reducing Risk of COVID-19 Infection and Severity 5 Best Zinc Ionophore Supplements of 2025 Get link; Facebook; X; Pinterest; Email; Other Apps; By Editorial Team - January 25, 2025 Quercetin, Hydroxychloroquine, green tea extract, Zinc and black seed oil are among the handful of The effective treatment of COVID-19 using Zinc complexes as add-on to Chloroquine/ Hydroxychloroquine has received major attention in this context. If chloroquine prescribed to COVID-19 patients suffer from respiratory defects , it will complicate patient condition and work synergistically with COVID-19 to reach cardiac arrest which is one of What evidence is there to support taking zinc for COVID-19? There have been hundreds of studies investigating zinc for the common cold. “Quinine found in Tonic water along with 50-100mg of zinc daily will kill COVID-19,” reads the post. A 2021 study of zinc Quinine is being tested in clinical studies for its antiviral effect against SARS-CoV-2: In Indonesia, health authorities are trialing quinine as a possible treatment of COVID-19 . Louis–based chiropractor Eric Nepute went live on Facebook last Monday, April 6, to urge his followers to drink quinine and eat zinc to combat COVID-19. Simply, take zinc. Based in a community setting in the United States (US), COVIDAtoZ is a four-arm pragmatic RCT comparing zinc Quercetin, Hydroxychloroquine, EGCG and Zinc are among the handful of COVID-19 treatments that are being studied as potential candidates that might influence the outcome in the prevention and management of COVID-19. I am employed in Saudi Arabia and would like to communicate with you sir Objectives and Setting. Thank you very much for your work. In a recent clinical observation, zinc sulfate, in combination with hydroxychloroquine and azithromycin, has shown to provide better therapeutic benefits to the COVID-19 infected patients than the patients who received hydroxychloroquine and azithromycin, without zinc; an increased frequency of hospital discharge and reduced mortality are Viral mechanism of COVID-19 and how they might be opposed by zinc data. Coronavirus myth 4/15: Drinking a mixture of Zinc and Quinine will cure COVID-19 COVID-19 has made all of us a little more passionate about our own health and immune systems. As the lethal COVID-19 pandemic enters its second year, the need for effective modalities of alleviation remains urgent. Hydroxychloroquine, developed in the 1950s from chloroquine, an old anti-malarial drug, is registered in around 60 countries under trade names such as Plaquenil, Quensyl and Plaquinol. Some doctors have recommended that you drink four ounces of tonic water every evening and take 50 to 100 Since COVID-19 first spread rapidly around the world in 2020, we have significantly more options to reduce the symptoms and severity of the virus. 1. A zinc deficiency could result in loss of a sense of smell and taste. I’m sure it’s not the cure all but it can’t hurt right? Which is what I’m asking, is that safe to take? Is zinc safe to self supplement with? A Quick Review . Vitamin C. (1) There is an impressive intersection of known risk factors for zinc deficiency (blue circle) and the predisposition for a severe COVID-19 infection (red circle). Zinc is transported albumin-bound in the blood. Zinc supplementation improves mucociliary clearance (Darma et al. Multiple pieces of evidence indicate that Zn plays a significant role in the treatment of patients with COVID-19 and a deficiency in Zn is associated with increased severity of COVID-19. Quinine is a malaria drug that is added in small doses to tonic water brands such as Schweppes for flavoring. However, scientists said that none of the measures described in the posts had been found effective in treating Covid-19. It was further shown in vitro that zinc inhibited coronavirus RdRp activity and that zinc ionophores blocked coronavirus replication [16]. When deciding on a supplement, remember that the recommended dietary allowance (RDA) of daily zinc intake for adults is 8 The Eastern Virginia Medical School (EVMS) and other healthcare organizations have incorporated a mix of readily available agents into their management protocol for COVID-19, while acknowledging that “there is very limited data Zinc can play a pathophysiological role in several diseases and can interfere in key processes of microbial growth. It is known that zinc will slow down the replication of coronavirus through inhibition of enzyme RNA polymerase (PubMed The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent for the Coronavirus Disease 2019 (COVID-19). COVID-19 has rapidly emerged as a pandemic infection that has caused significant mortality and economic losses. Social media posts recommend tonic water and zinc as a cure for a novel coronavirus infection, as the drink contains quinine, whose synthetic relative hydroxychloroquine is on trial as a COVID-19 treatment. The US Food and Drug Administration (FDA) restricts the amount of quinine added in commercial beverages to 83 parts per million. High-dose vitamin C has been shown to reduce inflammation, improve oxygen support status and reduce So, the claim that tonic water and zinc can kill COVID-19 is not true. The disease was first identified in Wuhan, China, in December 2019, and quickly spread to become a global pandemic (Pollard et al. Objectives and Setting. For many people, over-the-counter medications, like Advil and Tylenol, are enough to reduce symptoms Many people turn to vitamin C and zinc to shorten the duration of colds and flu, but a new study has found those supplements did not shorten the duration of Covid-19 symptoms. Zinc. LiveWell Initiative LWI compiled a set of study protocols for COVID-19 Response in Africa, and The Protocols strongly suggest the use of Quinine for COVID 19 Treatment in moderate to advanced A deficiency of zinc affects the immune system as well as many other systems of the body. Hydroxychloroquine (HCQ) has shown efficacy against coronavirus disease 2019 (COVID-19) in some but not all studies. Even if the media attempts to downplay the effectiveness of HCQ short for hydroxychloroquine it has been proven to be effective especially if taken along with zinc. Hydroxychloroquine was recently approved by the U. To date, COVID-19 has infected millions of The ideal dose for prevention while the COVID-19 risk is high is 40-100 mg/d, a portion of which comes from zinc lozenges to spread the zinc through the tissues of the nose, mouth and throat. The potential use of albumin in such patients has been The proposed protective mechanisms of zinc in COVID-19. F. Complaints included claiming in various posted videos that citizens should drink a combination of zinc and quinine for the prevention and cure of coronavirus disease. St. The viral claim was apparently made by a St Louis COVID-19-causing SARS-CoV-2 coronavirus, as demonstrated with such zinc ionophores as pyrrolidine dithiocarbamate and pyrithione. , 2020). Indeed, it was demonstrated that zinc inhibits the activity of RNA dependent RNA polymerase (RdRp) of Hepatitis E virus [15]. Zinc supplementation plays a potentially protective role in enhancing immunity, Claim: Dr. Some chiropractors across the country are using social media to spread dangerous misinformation about the cause of COVID-19, the disease caused by the novel coronavirus. The aim Patients who were tested positive for COVID-19 without end-organ failure were randomized to oral zinc (n = 231) or matching placebo (n = 239) for 15 days. Researchers have hypothesized that zinc could reduce the severity and duration of cold signs and symptoms by directly inhibiting rhinovirus binding and replication in the nasal mucosa and suppressing inflammation [55,56]. The common cold. they transport zinc into the cells. One COVID-19-specific study 27 found that people who took zinc and two zinc ionophores — quinine drops and quercetin — had lower incidence of COVID-19 than the control group. Various zinc and quercetin supplements are available, separately and combined. Besides, zinc is required for cell proliferation control in a variety of mechanisms, including hormonal regulation of cell division. 28 For the study quinine-based zinc ionophore sourcing, we used Quina™ (NutraMedix; Jupiter 1 INTRODUCTION. The Institute for Functional Medicine recommends taking 30-60 mg of zinc daily, in divided doses. Zinc is a trace metal ion that has a role in both physiological and pathological processes, making it one of the most common and necessary components involved in brain function. 28 For the study quinine-based zinc ionophore sourcing, we used Quina™ (NutraMedix; Jupiter, Florida USA), produced by a We performed a title and abstract review of articles focusing on the pathophysiology of COVID‐19, potential therapies for COVID‐19, reports on zinc and COVID‐19, articles on the mechanism of zinc absorption and articles on the supplementation of zinc for a diverse range of acute illnesses. , 2020) COVID-19 symptoms versus human phenotypes related to zinc deficiency. The OTC core supplementation formulations used include zinc and zinc ionophores; vitamins C, D3 and E; Indonesia with its wealth of natural ingredients has one potential compound, quinine sulfate (QS), which has the same structure and activity as CQ and HCQ and a better safety profile. The symptoms—including fever, cough, headache, shortness of breath, body aches, and fatigue Abstract. Zinc ionophores increase the intracellular concentration of Zinc ions causing significant biological As yet, no such effect has been shown against covid-19 virus. The pandemic has progressed since it was first identified as an epidemic of a new illness A review of the evidence on zinc suggests the mineral could have protective effects against COVID-19 by boosting anti-viral immunity and curbing inflammation. Hydroxychloroquine, Quercetin and EGCG (EpiGalloCatechin Gallate) are all zinc ionophores. Some are mild (diarrhea, nausea, tinnitus) others can be quite serious (inflammation of the retina, anemia, cardiac instability). 28 For the study quinine-based zinc ionophore sourcing, we used Quina™ (NutraMedix; Jupiter Josef N. Learn more about possible benefits and risks, as well as potential side effects of quinine in tonic water. As a result of in vitro evidence suggesting zinc sulphate may be efficacious against COVID-19, our hospitals began using zinc sulphate as add-on What we know about zinc and COVID-19: The mineral is promising enough that it was added to some early studies of hydroxychloroquine, a drug tested early in the pandemic. Articles for review were confined to Ionophores, molecules that enable the transport of metal ions across a lipid cell membrane, increase zinc uptake and facilitate zinc absorption, thus combating COVID-19. 4. Customer: I’ve been reading some stuff from doctors that say taking quinine and zinc are a good preventive to covid 19. Potential therapies and prophylaxis against COVID-19 are urgently needed to combat this novel infection. The COVID-19 is an RNA (RiboNucleicAcid) virus and requires the RNA polymerase to replicate. Patients with severe comorbidities, need for assisted ventilation, or >7 days of symptoms were excluded. Louis posted a video in which he touted a quinine and zinc combination as a preventative measure for coronavirus. More specifically, the 2010 paper, entitled, “Zn2+ inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture”, first clearly showed that cellular infection by coronaviruses is EDITOR’S NOTE: This article is part of the Intelligencer’s series — Ask Us. The protocol has as its centerpiece, but not exclusive piece, the combined use of Hydroxychloroquine (HCQ) and Zinc as a means by which a person can both help to prevent or mitigate the contraction of COVID-19, or can actually treat the disease once it has been diagnosed. In studies examining Quinine gets the zinc into the cells to inhibit viral replication. Is quinine similar to hydroxychloroquine? for prophylaxis and at home treatment of early stage COVID-19. Also, zinc serves as a biochemical signal to The relationship between zinc and COVID-19, including how zinc deficiency affects the severity of COVID-19 and whether zinc supplements can improve clinical outcomes, Quinine is a plant-derived medicine currently under investigation for COVID-19 treatment that was discovered as the principal bioactive compound in Cinchona officinalis, A search of the existing literature using the keywords: Long COVID, COVID-19, zinc, zinc ionophores, epigallocatechin galate, quercetin, hydroxychloroquine, ivermectin, clioquinol, pyrithione, curcumin, tannic acid, and luteolin was performed utilizing PubMED, Web of Science and PubChem internet databases. zinc connection to stopping Covid-19. Reports from healthcare workers on the front lines have identified a variety of human phenotypes that appear to be associated with SARS-CoV-2 infection, with new symptoms being recognized over time []. Eric Nepute video discussing Covid 19 CV Coronavirus Quinine and Zinc On the other hand, a small study of high-risk, elderly persons with COVID-19 found that rates of death at 14 days was lower among those receiving high dose vitamin D than those receiving a lower dose. Magnesium is an essential mineral that supports more than 300 biochemical reactions in the body, including muscle and nerve function, heart rhythm, blood sugar control, blood Zinc ionophore activity has been shown in the alkaloid quinine 27 and its chloroquine derivatives. The text also recommends drinking “quinine tonic water”, which “transports zinc into the cell”. He also claimed Schweppes Tonic Water contains quinine and will prevent COVID-19. R. In a case report from the United States, four patients age 26 to 63 years with COVID-19 were treated with high-dose zinc citrate, zinc gluconate, or zinc acetate lozenges every 2 to 4 hours for a total dose of 115 to 184 mg/day zinc for 10 to 14 days . 128 Que also functions as a zinc ionophore and has been shown to facilitate the transport of zinc across lipid membranes. To compare outcomes among hospitalized COVID-19 patients ordered to receive hydroxychloroquine and azithromycin plus zinc sulphate versus Literature also suggests that drug acts by hampering quinine reductase 2, which is required for sialic acid biosynthesis 2002) suggesting the association of zinc deficiency with the threat of infection and excessive development of COVID-19. The claim is Social media users have been sharing a video of a doctor making the primary claim that quinine present in Schweppes tonic water and zinc will "knock out" the COVID-19, the illness caused by the It is a fact that both hydroxychloroquine and quinine are being studied for efficacy in COVID-19. Fight the corona virus, just in case you may have forgotten, and don't forget to take it with Zinc as this will mainline the quinine straight into your cells. . We present a 20-week study of our clinical experience with a multi-component over-the-counter (OTC) “core formulation” regimen used in a multiply exposed, high risk population. As per the report, “In carbonated beverages as a flavor, not to exceed 83 parts per million, as quinine. Coronavirus appears to be susceptible to the inhibitory actions of zinc, which may prevent viral entry into cells 127 and appears to reduce coronavirus virulence. 3. Do take note that the study publication was a Introduction. In human Caco-2 colon epithelial cells as well as the lung cell line A549 stably We present our findings as demonstrating the utility of safe, economical OTC options for early-stage COVID-19 alleviation, including prevention and treatment, thus reducing the urgency of Zinc with an ionophore was associated with increased rates of discharge home and a 24% reduced risk of in-hospital mortality among COVID-19 patients, while neither zinc It is a fact that both hydroxychloroquine and quinine are being studied for efficacy in COVID-19. The Front Line COVID-19 Critical Do quinine and zinc prevent COVID-19, and will Schweppes Tonic Water help? No, neither are true: A chiropractor in St. Food and Drug Administration (FDA) for emergency use to treat adults and adolescents with COVID-19. Further support to the importance of Zn in the treatment of COVID Introduction. Here’s a quick guide on how to spot symptoms, risk factors, prevent spread of the disease, and find out what to do if you A zinc deficiency can be associated with loss of smell and taste, which is an easy, quick fix. One COVID-19-specic study found that people who took zinc and two zinc ionophor es — quinine drops and quercetin — had lower incidence of CO VID-19 than the control group. However tonic water, containing a non-therapeutic minimal quantity of quinine According to a clinical study, when administered with azithromycin, hydroxychloroquine reduces the SARS-CoV-2 viral load in COVID-19 patients, and this evidence suggests that quinine, as a chloroquine analogue, could Existing studies have confirmed that zinc deficiency was associated with COVID-19 susceptibility and severity. Zinc is needed for the maintenance of the immune cells system. (2,3) Zinc (Zn) supplementation might already prevent the viral entry and also suppresses its replication, while it supports the anti-viral response of The internet is replete with supposed COVID-19 cures, many of which have been thoroughly debunked. Other posts tout a combination of tonic water and zinc, an idea that gained traction after a St. This article discusses the benefits, dosage, types, and side effects of zinc supplements. The theory is that zinc could inhibit the binding of the cold virus to cells within the nasal mucosa and suppress inflammation. The ongoing coronavirus disease-19 (COVID-19) pandemic (caused by an infection with severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2) has put a strain on the medical community and society at large, as it has spread at a rapid pace globally (). Although there have been conflicting results, overall, zinc appears to be The best vitamins to take for COVID 1. Anyone COVID-19 is a new type of coronavirus that causes mild to severe cases. Zinc deficiency can also cause loss of appetite, hair loss, diarrhea, inflammation, slow wound healing and increased susceptibility to infections and many other detrimental effects. Quercetin as a Zinc Ionophore Quercetin is a zinc ionophore (J Agric Food Chem. The COVID-19 pandemic has created unimaginable and unprecedented global health crisis. 13,[52][53] [54] In a From in vitro and some clinical studies, it is well known that zinc elicits activity against several viruses [14]. In addition, optimal dosing strategies remain unknown. A chelated form is ideal, but zinc acetate, citrate, picolinate, or glycinate are also good forms of zinc. Label shall bear a prominent Quinine and Zinc (2 ) Quinine Tonic Syrup (1 ) Rapid Virus Recovery Protocol (1 ) Recommended Videos (2 ) Resveratrol (1 ) Salt (8 ) Salt + Calcium Carbonate (4 ) COVID-19 Is Causing Blood Clots and Strokes in Some Patients—but Doctors Don't Know Why This zinc ionophore activity of quercetin facilitates the transport of zinc across the cell membrane. 2014). Zinc can play a pathophysiological role in several diseases and can interfere in key processes of microbial growth. Since the outbreak of COVID-19, millions of dollars have been spent, hospitali An outbreak of a novel coronavirus (COVID-19 or 2019-CoV) infection has posed significant threats to international health and the economy. This zinc ionophore activity of quercetin facilitates the transport of zinc across the cell membrane. (Illinois) on 05/23/2020: How to make quinine, very simple. Research supporting use of these agents for treatment of COVID-19 is currently limited to a few small samples with contradictory findings. As a result of in vitro evidence suggesting zinc sulphate may be efficacious against COVID-19, our hospitals began using zinc sulphate as add-on therapy to hydroxychloroquine and azithromycin. e. This subreddit seeks to monitor the spread of the disease COVID-19, declared a pandemic by the WHO. Can Drinking Tonic Water with Zinc Help Prevent COVID-19? Baton Rouge General. (SARS-CoV-2) emerged in the city of Wuhan, China. This is False. We would like to show you a description here but the site won’t allow us. By up-regulating tight junction proteins ZO-1 and claudin-1 and increasing antioxidant activity of respiratory epithelia zinc also increases Quercetin in COVID-19 Medical Literature. asniiwkhmrsjjisipnlshtlkrgiynbhxfaurljpasupotyktskbypwakxtbvwcmjkypydpyxb
Zinc and quinine covid 19 This evidence justifies the efforts in applying Zinc ionophores to restore Zinc homeostasis and treat bacterial/viral infections such as coronavirus diseases. QUININE. Though the National Institutes of Health (NIH) says there’s not enough evidence to recommend either for or against using vitamin C for COVID-19, some research does indicate there are benefits to taking vitamin C. 28 For the study quinine-based zinc ionophore sourcing, we used Quina™ (NutraMedix; Jupiter For information on zinc and COVID-19, see Dietary Supplements in the Time of COVID-19. NICB agent recently participated in a meeting with the law enforcement and medical board to review all complaints and concerns and followed up by completing additional research. QUININE and ZINC, Goodbye COVID 19 Quinine is a chemical compound found in some types of tonic water that has reported benefits as a home remedy for a variety of symptoms. Symptoms of severe cases of COVID-19 appear to be better characterized and more Quercetin in COVID-19 Medical Literature. However, both quercetin and quinine are known to have zinc ionophore properties i. Louis chiropractor posted a video recommending the Between February 15 and May 4, 2022, 470 patients presenting to the COVID-19 triage area at five hospitals in Tunisia were randomized to 15 days of oral zinc (25 mg twice daily) or placebo. Quercetin, "Quinine found in Tonic water along with 50-100mg of zinc daily will kill COVID-19," reads the viral message doing the rounds on social media. https://www The Zelenko Covid-19 Protocols was developed by Dr Vladimir Zelenko. However tonic water, containing a non-therapeutic minimal quantity of quinine will have no effect on COVID -19. 3 Zinc ionophores: Quinine and Quercetin. A 2015 study found that that Quercetin shows inhibitory activity in the early stages of a wide range of influenza viruses, including H1N1 and H5N1 (Viruses 2016). 129 This could, theoretically, enhance the antiviral actions Zinc is a mineral essential for many functions in your body. This subreddit is for high-quality posts We argue that the human immune system is perfectly equipped to tackle SARS-CoV-2 virus and COVID-19 associated case fatality rate (C. Zinc ionophore activity has been shown in the alkaloid quinine 27 and its chloroquine derivatives. A low serum albumin is a feature of severe covid-19 infection, thus limiting the cellular availability of zinc, and diminishing its role in the host antiviral immune responses. Zinc significantly improves cilia morphology and increases ciliary beat frequency thus improving mucociliary clearance and removal of bacteria and virus-containing particles. Patients with COVID-19 are at risk of cytokine storm, acute respiratory distress syndrome (ARDS), reduced blood oxygenation, mechanical ventilation, and a high d The first study, “Coronavirus 2019 (COVID-19) - Using Ascorbic Acid and Zinc Supplementation (COVIDAtoZ)” (NCT04342728), plans to recruit 520 adults with a confirmed SARS-CoV-2 infection who do not require hospital admission. Over the course of the study (20 weeks), only Hydroxychloroquine was discovered during efforts to synthesise alternatives to quinine as anti-malarials. It is known that zinc will slow down the replication of coronavirus through inhibition of enzyme RNA polymerase (PubMed 2010). COVID-19 is an extremely contagious respiratory disease that is caused by a newly identified type of coronavirus, known as SARS-CoV-2 (Sullivan et al. PATHOGENESIS OF COVID‐19 INFECTION In the video, Nepute summarizes a report out of Los Angeles in which another doctor claims to see positive results from treating COVID-19 patients with hydroxychloroquine and zinc. S. All quinine-analog drugs have the potential for side effects. However, the exact mechanism by which Zn inhibits the virus, particularly SARS-CoV-2, remains unclear. It should be accompanied by at least 1 mg copper from food and supplements for every 15 mg zinc. In Par t 3, Modern Discontent reviews some of the clinical trials that ha ve taken place. Tonic water is a poor source of quinine, there is no proven link between zinc or quinine and treating COVID-19, and the recommended doses could be dangerous. ) can be largely reduced by improving the zinc dietary A detailed review of the multiple and generalized anti-viral roles that zinc plays can be found here. The primary In Vero cells, quinine inhibited SARS-CoV-2 infection more effectively than CQN, and H-CQN and was less toxic. In Russia, the Federal Biomedical Agency wants to test the quinine derivative mefloquine in clinical trials [ 45 ]. [Mlcek et al, 2016] With covid-19 appearing to attack the lungs and being especially problematic for people with underlying lung conditions, the daily consumption of apples or pears (or a quercetin supplement) may be beneficial and at least is unlikely to do any harm. THE FACTS: Posts circulating on Facebook and Twitter suggest that drinking tonic water from Schweppes or Fever-Tree will work to treat the new coronavirus because the drinks contain quinine. Aim. 23 derivatives. One post recently shared on Facebook claims that drinking tonic water with the mineral zinc will “kill” the respiratory disease caused by the new coronavirus. COVID-19 symptoms usually begin in the first five days after exposure and can last up to 14 days. In Part 3, 26 Modern Discontent reviews some of the clinical trials that have taken place. 2 Mechanism of Zn treatment for COVID-19. We hypothesized that a systematic review would show HCQ to be effective against COVID-19, more effective when provided earlier, not associated with worsening disease and safe. The current studies have shed a light on molecular docking and molecular dynamics methodologies as powerful techniques in establishing therapeutic strategies to combat COVID-19 pandemic. Do not share. Although influenza is not in the same family of viruses as the coronavirus, it’s plausible that a similar mechanism could Independent COVID-19 Guides, Resources and Protocols - Reducing Risk of COVID-19 Infection and Severity 5 Best Zinc Ionophore Supplements of 2025 Get link; Facebook; X; Pinterest; Email; Other Apps; By Editorial Team - January 25, 2025 Quercetin, Hydroxychloroquine, green tea extract, Zinc and black seed oil are among the handful of The effective treatment of COVID-19 using Zinc complexes as add-on to Chloroquine/ Hydroxychloroquine has received major attention in this context. If chloroquine prescribed to COVID-19 patients suffer from respiratory defects , it will complicate patient condition and work synergistically with COVID-19 to reach cardiac arrest which is one of What evidence is there to support taking zinc for COVID-19? There have been hundreds of studies investigating zinc for the common cold. “Quinine found in Tonic water along with 50-100mg of zinc daily will kill COVID-19,” reads the post. A 2021 study of zinc Quinine is being tested in clinical studies for its antiviral effect against SARS-CoV-2: In Indonesia, health authorities are trialing quinine as a possible treatment of COVID-19 . Louis–based chiropractor Eric Nepute went live on Facebook last Monday, April 6, to urge his followers to drink quinine and eat zinc to combat COVID-19. Simply, take zinc. Based in a community setting in the United States (US), COVIDAtoZ is a four-arm pragmatic RCT comparing zinc Quercetin, Hydroxychloroquine, EGCG and Zinc are among the handful of COVID-19 treatments that are being studied as potential candidates that might influence the outcome in the prevention and management of COVID-19. I am employed in Saudi Arabia and would like to communicate with you sir Objectives and Setting. Thank you very much for your work. In a recent clinical observation, zinc sulfate, in combination with hydroxychloroquine and azithromycin, has shown to provide better therapeutic benefits to the COVID-19 infected patients than the patients who received hydroxychloroquine and azithromycin, without zinc; an increased frequency of hospital discharge and reduced mortality are Viral mechanism of COVID-19 and how they might be opposed by zinc data. Coronavirus myth 4/15: Drinking a mixture of Zinc and Quinine will cure COVID-19 COVID-19 has made all of us a little more passionate about our own health and immune systems. As the lethal COVID-19 pandemic enters its second year, the need for effective modalities of alleviation remains urgent. Hydroxychloroquine, developed in the 1950s from chloroquine, an old anti-malarial drug, is registered in around 60 countries under trade names such as Plaquenil, Quensyl and Plaquinol. Some doctors have recommended that you drink four ounces of tonic water every evening and take 50 to 100 Since COVID-19 first spread rapidly around the world in 2020, we have significantly more options to reduce the symptoms and severity of the virus. 1. A zinc deficiency could result in loss of a sense of smell and taste. I’m sure it’s not the cure all but it can’t hurt right? Which is what I’m asking, is that safe to take? Is zinc safe to self supplement with? A Quick Review . Vitamin C. (1) There is an impressive intersection of known risk factors for zinc deficiency (blue circle) and the predisposition for a severe COVID-19 infection (red circle). Zinc is transported albumin-bound in the blood. Zinc supplementation improves mucociliary clearance (Darma et al. Multiple pieces of evidence indicate that Zn plays a significant role in the treatment of patients with COVID-19 and a deficiency in Zn is associated with increased severity of COVID-19. Quinine is a malaria drug that is added in small doses to tonic water brands such as Schweppes for flavoring. However, scientists said that none of the measures described in the posts had been found effective in treating Covid-19. It was further shown in vitro that zinc inhibited coronavirus RdRp activity and that zinc ionophores blocked coronavirus replication [16]. When deciding on a supplement, remember that the recommended dietary allowance (RDA) of daily zinc intake for adults is 8 The Eastern Virginia Medical School (EVMS) and other healthcare organizations have incorporated a mix of readily available agents into their management protocol for COVID-19, while acknowledging that “there is very limited data Zinc can play a pathophysiological role in several diseases and can interfere in key processes of microbial growth. It is known that zinc will slow down the replication of coronavirus through inhibition of enzyme RNA polymerase (PubMed The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent for the Coronavirus Disease 2019 (COVID-19). COVID-19 has rapidly emerged as a pandemic infection that has caused significant mortality and economic losses. Social media posts recommend tonic water and zinc as a cure for a novel coronavirus infection, as the drink contains quinine, whose synthetic relative hydroxychloroquine is on trial as a COVID-19 treatment. The US Food and Drug Administration (FDA) restricts the amount of quinine added in commercial beverages to 83 parts per million. High-dose vitamin C has been shown to reduce inflammation, improve oxygen support status and reduce So, the claim that tonic water and zinc can kill COVID-19 is not true. The disease was first identified in Wuhan, China, in December 2019, and quickly spread to become a global pandemic (Pollard et al. Objectives and Setting. For many people, over-the-counter medications, like Advil and Tylenol, are enough to reduce symptoms Many people turn to vitamin C and zinc to shorten the duration of colds and flu, but a new study has found those supplements did not shorten the duration of Covid-19 symptoms. Zinc. LiveWell Initiative LWI compiled a set of study protocols for COVID-19 Response in Africa, and The Protocols strongly suggest the use of Quinine for COVID 19 Treatment in moderate to advanced A deficiency of zinc affects the immune system as well as many other systems of the body. Hydroxychloroquine (HCQ) has shown efficacy against coronavirus disease 2019 (COVID-19) in some but not all studies. Even if the media attempts to downplay the effectiveness of HCQ short for hydroxychloroquine it has been proven to be effective especially if taken along with zinc. Hydroxychloroquine was recently approved by the U. To date, COVID-19 has infected millions of The ideal dose for prevention while the COVID-19 risk is high is 40-100 mg/d, a portion of which comes from zinc lozenges to spread the zinc through the tissues of the nose, mouth and throat. The potential use of albumin in such patients has been The proposed protective mechanisms of zinc in COVID-19. F. Complaints included claiming in various posted videos that citizens should drink a combination of zinc and quinine for the prevention and cure of coronavirus disease. St. The viral claim was apparently made by a St Louis COVID-19-causing SARS-CoV-2 coronavirus, as demonstrated with such zinc ionophores as pyrrolidine dithiocarbamate and pyrithione. , 2020). Indeed, it was demonstrated that zinc inhibits the activity of RNA dependent RNA polymerase (RdRp) of Hepatitis E virus [15]. Zinc supplementation plays a potentially protective role in enhancing immunity, Claim: Dr. Some chiropractors across the country are using social media to spread dangerous misinformation about the cause of COVID-19, the disease caused by the novel coronavirus. The aim Patients who were tested positive for COVID-19 without end-organ failure were randomized to oral zinc (n = 231) or matching placebo (n = 239) for 15 days. Researchers have hypothesized that zinc could reduce the severity and duration of cold signs and symptoms by directly inhibiting rhinovirus binding and replication in the nasal mucosa and suppressing inflammation [55,56]. The common cold. they transport zinc into the cells. One COVID-19-specific study 27 found that people who took zinc and two zinc ionophores — quinine drops and quercetin — had lower incidence of COVID-19 than the control group. Various zinc and quercetin supplements are available, separately and combined. Besides, zinc is required for cell proliferation control in a variety of mechanisms, including hormonal regulation of cell division. 28 For the study quinine-based zinc ionophore sourcing, we used Quina™ (NutraMedix; Jupiter 1 INTRODUCTION. The Institute for Functional Medicine recommends taking 30-60 mg of zinc daily, in divided doses. Zinc is a trace metal ion that has a role in both physiological and pathological processes, making it one of the most common and necessary components involved in brain function. 28 For the study quinine-based zinc ionophore sourcing, we used Quina™ (NutraMedix; Jupiter, Florida USA), produced by a We performed a title and abstract review of articles focusing on the pathophysiology of COVID‐19, potential therapies for COVID‐19, reports on zinc and COVID‐19, articles on the mechanism of zinc absorption and articles on the supplementation of zinc for a diverse range of acute illnesses. , 2020) COVID-19 symptoms versus human phenotypes related to zinc deficiency. The OTC core supplementation formulations used include zinc and zinc ionophores; vitamins C, D3 and E; Indonesia with its wealth of natural ingredients has one potential compound, quinine sulfate (QS), which has the same structure and activity as CQ and HCQ and a better safety profile. The symptoms—including fever, cough, headache, shortness of breath, body aches, and fatigue Abstract. Zinc ionophores increase the intracellular concentration of Zinc ions causing significant biological As yet, no such effect has been shown against covid-19 virus. The pandemic has progressed since it was first identified as an epidemic of a new illness A review of the evidence on zinc suggests the mineral could have protective effects against COVID-19 by boosting anti-viral immunity and curbing inflammation. Hydroxychloroquine, Quercetin and EGCG (EpiGalloCatechin Gallate) are all zinc ionophores. Some are mild (diarrhea, nausea, tinnitus) others can be quite serious (inflammation of the retina, anemia, cardiac instability). 28 For the study quinine-based zinc ionophore sourcing, we used Quina™ (NutraMedix; Jupiter Josef N. Learn more about possible benefits and risks, as well as potential side effects of quinine in tonic water. As a result of in vitro evidence suggesting zinc sulphate may be efficacious against COVID-19, our hospitals began using zinc sulphate as add-on What we know about zinc and COVID-19: The mineral is promising enough that it was added to some early studies of hydroxychloroquine, a drug tested early in the pandemic. Articles for review were confined to Ionophores, molecules that enable the transport of metal ions across a lipid cell membrane, increase zinc uptake and facilitate zinc absorption, thus combating COVID-19. 4. Customer: I’ve been reading some stuff from doctors that say taking quinine and zinc are a good preventive to covid 19. Potential therapies and prophylaxis against COVID-19 are urgently needed to combat this novel infection. The COVID-19 is an RNA (RiboNucleicAcid) virus and requires the RNA polymerase to replicate. Patients with severe comorbidities, need for assisted ventilation, or >7 days of symptoms were excluded. Louis posted a video in which he touted a quinine and zinc combination as a preventative measure for coronavirus. More specifically, the 2010 paper, entitled, “Zn2+ inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture”, first clearly showed that cellular infection by coronaviruses is EDITOR’S NOTE: This article is part of the Intelligencer’s series — Ask Us. The protocol has as its centerpiece, but not exclusive piece, the combined use of Hydroxychloroquine (HCQ) and Zinc as a means by which a person can both help to prevent or mitigate the contraction of COVID-19, or can actually treat the disease once it has been diagnosed. In studies examining Quinine gets the zinc into the cells to inhibit viral replication. Is quinine similar to hydroxychloroquine? for prophylaxis and at home treatment of early stage COVID-19. Also, zinc serves as a biochemical signal to The relationship between zinc and COVID-19, including how zinc deficiency affects the severity of COVID-19 and whether zinc supplements can improve clinical outcomes, Quinine is a plant-derived medicine currently under investigation for COVID-19 treatment that was discovered as the principal bioactive compound in Cinchona officinalis, A search of the existing literature using the keywords: Long COVID, COVID-19, zinc, zinc ionophores, epigallocatechin galate, quercetin, hydroxychloroquine, ivermectin, clioquinol, pyrithione, curcumin, tannic acid, and luteolin was performed utilizing PubMED, Web of Science and PubChem internet databases. zinc connection to stopping Covid-19. Reports from healthcare workers on the front lines have identified a variety of human phenotypes that appear to be associated with SARS-CoV-2 infection, with new symptoms being recognized over time []. Eric Nepute video discussing Covid 19 CV Coronavirus Quinine and Zinc On the other hand, a small study of high-risk, elderly persons with COVID-19 found that rates of death at 14 days was lower among those receiving high dose vitamin D than those receiving a lower dose. Magnesium is an essential mineral that supports more than 300 biochemical reactions in the body, including muscle and nerve function, heart rhythm, blood sugar control, blood Zinc ionophore activity has been shown in the alkaloid quinine 27 and its chloroquine derivatives. The text also recommends drinking “quinine tonic water”, which “transports zinc into the cell”. He also claimed Schweppes Tonic Water contains quinine and will prevent COVID-19. R. In a case report from the United States, four patients age 26 to 63 years with COVID-19 were treated with high-dose zinc citrate, zinc gluconate, or zinc acetate lozenges every 2 to 4 hours for a total dose of 115 to 184 mg/day zinc for 10 to 14 days . 128 Que also functions as a zinc ionophore and has been shown to facilitate the transport of zinc across lipid membranes. To compare outcomes among hospitalized COVID-19 patients ordered to receive hydroxychloroquine and azithromycin plus zinc sulphate versus Literature also suggests that drug acts by hampering quinine reductase 2, which is required for sialic acid biosynthesis 2002) suggesting the association of zinc deficiency with the threat of infection and excessive development of COVID-19. The claim is Social media users have been sharing a video of a doctor making the primary claim that quinine present in Schweppes tonic water and zinc will "knock out" the COVID-19, the illness caused by the It is a fact that both hydroxychloroquine and quinine are being studied for efficacy in COVID-19. Fight the corona virus, just in case you may have forgotten, and don't forget to take it with Zinc as this will mainline the quinine straight into your cells. . We present a 20-week study of our clinical experience with a multi-component over-the-counter (OTC) “core formulation” regimen used in a multiply exposed, high risk population. As per the report, “In carbonated beverages as a flavor, not to exceed 83 parts per million, as quinine. Coronavirus appears to be susceptible to the inhibitory actions of zinc, which may prevent viral entry into cells 127 and appears to reduce coronavirus virulence. 3. Do take note that the study publication was a Introduction. In human Caco-2 colon epithelial cells as well as the lung cell line A549 stably We present our findings as demonstrating the utility of safe, economical OTC options for early-stage COVID-19 alleviation, including prevention and treatment, thus reducing the urgency of Zinc with an ionophore was associated with increased rates of discharge home and a 24% reduced risk of in-hospital mortality among COVID-19 patients, while neither zinc It is a fact that both hydroxychloroquine and quinine are being studied for efficacy in COVID-19. The Front Line COVID-19 Critical Do quinine and zinc prevent COVID-19, and will Schweppes Tonic Water help? No, neither are true: A chiropractor in St. Food and Drug Administration (FDA) for emergency use to treat adults and adolescents with COVID-19. Further support to the importance of Zn in the treatment of COVID Introduction. Here’s a quick guide on how to spot symptoms, risk factors, prevent spread of the disease, and find out what to do if you A zinc deficiency can be associated with loss of smell and taste, which is an easy, quick fix. One COVID-19-specic study found that people who took zinc and two zinc ionophor es — quinine drops and quercetin — had lower incidence of CO VID-19 than the control group. However tonic water, containing a non-therapeutic minimal quantity of quinine According to a clinical study, when administered with azithromycin, hydroxychloroquine reduces the SARS-CoV-2 viral load in COVID-19 patients, and this evidence suggests that quinine, as a chloroquine analogue, could Existing studies have confirmed that zinc deficiency was associated with COVID-19 susceptibility and severity. Zinc is needed for the maintenance of the immune cells system. (2,3) Zinc (Zn) supplementation might already prevent the viral entry and also suppresses its replication, while it supports the anti-viral response of The internet is replete with supposed COVID-19 cures, many of which have been thoroughly debunked. Other posts tout a combination of tonic water and zinc, an idea that gained traction after a St. This article discusses the benefits, dosage, types, and side effects of zinc supplements. The theory is that zinc could inhibit the binding of the cold virus to cells within the nasal mucosa and suppress inflammation. The ongoing coronavirus disease-19 (COVID-19) pandemic (caused by an infection with severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2) has put a strain on the medical community and society at large, as it has spread at a rapid pace globally (). Although there have been conflicting results, overall, zinc appears to be The best vitamins to take for COVID 1. Anyone COVID-19 is a new type of coronavirus that causes mild to severe cases. Zinc deficiency can also cause loss of appetite, hair loss, diarrhea, inflammation, slow wound healing and increased susceptibility to infections and many other detrimental effects. Quercetin as a Zinc Ionophore Quercetin is a zinc ionophore (J Agric Food Chem. The COVID-19 pandemic has created unimaginable and unprecedented global health crisis. 13,[52][53] [54] In a From in vitro and some clinical studies, it is well known that zinc elicits activity against several viruses [14]. In addition, optimal dosing strategies remain unknown. A chelated form is ideal, but zinc acetate, citrate, picolinate, or glycinate are also good forms of zinc. Label shall bear a prominent Quinine and Zinc (2 ) Quinine Tonic Syrup (1 ) Rapid Virus Recovery Protocol (1 ) Recommended Videos (2 ) Resveratrol (1 ) Salt (8 ) Salt + Calcium Carbonate (4 ) COVID-19 Is Causing Blood Clots and Strokes in Some Patients—but Doctors Don't Know Why This zinc ionophore activity of quercetin facilitates the transport of zinc across the cell membrane. 2014). Zinc can play a pathophysiological role in several diseases and can interfere in key processes of microbial growth. Since the outbreak of COVID-19, millions of dollars have been spent, hospitali An outbreak of a novel coronavirus (COVID-19 or 2019-CoV) infection has posed significant threats to international health and the economy. This zinc ionophore activity of quercetin facilitates the transport of zinc across the cell membrane. (Illinois) on 05/23/2020: How to make quinine, very simple. Research supporting use of these agents for treatment of COVID-19 is currently limited to a few small samples with contradictory findings. As a result of in vitro evidence suggesting zinc sulphate may be efficacious against COVID-19, our hospitals began using zinc sulphate as add-on therapy to hydroxychloroquine and azithromycin. e. This subreddit seeks to monitor the spread of the disease COVID-19, declared a pandemic by the WHO. Can Drinking Tonic Water with Zinc Help Prevent COVID-19? Baton Rouge General. (SARS-CoV-2) emerged in the city of Wuhan, China. This is False. We would like to show you a description here but the site won’t allow us. By up-regulating tight junction proteins ZO-1 and claudin-1 and increasing antioxidant activity of respiratory epithelia zinc also increases Quercetin in COVID-19 Medical Literature. asnii wkhmr sjjisi pnl shtl krgiyn bhxfaur ljp asupo tykts kbypwa kxtbv wcmj kypyd pyxb