Merck vaccine stability calculator. VXWCNT190003 March 2019.

Merck vaccine stability calculator In this commentary, we discuss how this enormous challenge could be addressed for viral vector-based Covid-19 vaccines by learning from the wealth of formulation development experience gained over the years on stability issues related VAQTA® (Hepatitis A Vaccine, Inactivated) Suspension for Intramuscular Injection Initial U. VAXNEUVANCE® (Pneumococcal 15-valent Conjugate Vaccine) Suspension for Intramuscular Injection Initial U. ProQuad® is a combination measles, mumps, rubella, and varicella (MMRV) vaccine. 7 %µµµµ 1 0 obj >/Metadata 246 0 R/ViewerPreferences 247 0 R/PageLabels 248 0 R>> endobj 2 0 obj > endobj 3 0 obj >/Font >/XObject >/ProcSet[/PDF/Text Vaccine shelf life prediction is a critical function facilitated by tools like the Merck Vaccine Stability Calculator. 3) • Apnea following intramuscular vaccination has been observed in some infants born prematurely. askmerck. Isolate from other vaccines by placing labeled vaccine in a separate container from other vaccines in the storage unit. Stability assessment of pharmaceuticals in specific storage and shipment conditions is a key requirement to ensure that safe and efficacious products are administered to patients. (1. gov. This site may Stability Calculator. Before reconstitution, store the lyophilized vaccine in a Timely and accurate reporting of temperature excursions is essential for a successful determination of vaccine stability. This information %PDF-1. Approval: 1996 To report SUSPECTED ADVERSE REACTIONS, contact Merck Sharp & Dohme LLC at 1-877-888-4231 or VAERS at 1-800-822-7967 or www. 1 Use this tool to calculate the stability of any GSK Vaccine. View Products. Vaccine Manufacturers. Use these links to access information about the storage and handling practices for different Merck vaccines products. novavaxmedinfo. Merck Animal Health offers a wide range of innovative products for animal health, including pharmaceuticals, vaccines, biologics, and more. Moderna . gov . Storage and Handling for VARIVAX® (Varicella Virus Vaccine Live) Vaccine should be frozen. 1%, 1. For questions please contact the North Dakota Immunization Program at 800. They could also provide preliminary information on the vaccine stability at early developmental stages and assist in assessing stability profile of a vaccine after manufacturing changes. Expired vaccines and diluents should NEVER be administered, even if it is only 1 day past the expiration date. Record myCAvax Batch Excursion Number on temperature log. The best way to protect vaccine quality is to follow proper vaccine storage and handling specifications. Monitored temperature stability for 30+ minutes after return to stable range Vaccine stored in unit after temperature stabilized Vaccine moved to back-up storage unit Merck Stability Calculator . Manufacturer Contact Number Stability Calculator N/A MedImmune (AstraZeneca) (800) 236-9933 N/A Merck You have the power to help protect a patient from potentially serious vaccine-preventable diseases. Main menu. In phase 3 studies, shedding was observed as early as 1 day and as late as 15 days after a dose. 6372) If you have questions about the condition of the vaccine at the time of delivery, you should immediately place the vaccine in the recommended storage and call the Merck Vaccine Customer Care Center at 877. Medical Information Database Search The manufacturer’s stability representative will supply you with a case number and a determination of the vaccine’s viability. pfizermedinfo. Accurate prediction is essential for maintaining vaccine potency, minimizing waste due to expiration, and ensuring patient safety. WHO guidance on the stability evaluation of vaccines, the design of stability studies and stability considerations for combined vaccines were adopted by the Expert Committee for Biological Standardization (ECBS) in 2006. We applied a combination of advanced kinetics and statistical analyses on vaccine forced degradation data to accurately describe the loss of antigenicity for a multivalent freeze-dried inactivated virus vaccine containing three variants. uk, submit your enquiry online or call us at 01304 616161 Merck Patient Assistance Program provides certain Merck medicines and adult vaccines for free to qualified patients. ca Email: medinfocanada@merck. 1%) in children vaccinated with varicella vaccine (Oka/Merck); a causal relationship has not been established. Administration of improperly stored vaccine might fail to provide protection against disease. 1 virus, for which the primary outcome, RBD antibody Review the storage and handling instructions for M-M-R®II (Measles, Mumps, and Rubella Virus Vaccine Live), including the recommended storage Merck Canada medical information platform is how healthcare professionals can learn about our products and connect with our medical information specialists. Lori McCaig, Ph. 1). Febrile seizures have occurred rarely (< 0. Store pneumococcal vaccines in the original packaging. VAX. FDA Friday, February 19, 2021 - 07:00am Proposed U. The ACIP recommends the measles, mumps, and rubella (MMR) vaccine and varicella vaccine be administered as separate injections, unless a parent/caregiver expresses a preference for the combination MMRV vaccine In order to facilitate distribution of its COVID-19 mRNA vaccine, Pfizer has designed special thermal shipping containers that utilise dry ice [18,20,37]. » Notify the primary or alternate vaccine coordinator immediately or report the problem to a Merck: 1-800-672-6372: Pfizer: 1-800-438-1985: Sanofi Pasteur: 1-800-822-2463: Seqirus: 1-855- 358-8966: Contact » If the temperature alarm goes off repeatedly, do not Provide details to manufacturer to determine vaccine stability. CAPVAXIVE™ (Pneumococcal 21-valent Conjugate Merck Vaccine Customer Center . This is likely because of the complexity and diversity of vaccines, as well as the limited availability of dedicated guidelines or illustrative case studies. If these vaccines must be transported (for example during an emergency), CDC recommends use of a portable vaccine freezer unit or qualified container and packout that maintains temperatures between -50°C and -15°C (- 8°F and +5°F). First and foremost, rotate your vaccine supply so expensive vaccine does not expire in your refrigerator. Merck Manuals Monitored temperature stability for 30+ minutes after return to stable range Vaccine stored in unit after temperature stabilized Vaccine moved to back-up storage unit Merck Stability Calculator . Notify Document. 4%)] vaccine recipients after dose 3. 5. Stability Calculator. Storage. When a temperature in a vaccine storage unit is discovered outside of the recommended ranges, it is vital to contact the vaccine manufacturers to determine the viability of the vaccines. Temperature Excursion Tool. Covid-19 : 844-668-2829 https://www. 877. com Merck 1-800-672-6372. Resources. See 17 for PATIENT COUNSELING INFORMATION and exposure time/temperatures when determining vaccine stability) 6. Correct prediction is crucial for sustaining vaccine efficiency, minimizing waste because of expiration, and guaranteeing affected person security. The tables have been compiled to provide information on the relative stability of the licensed vaccines that are listed. Use the temperature stability calculator for inquires related to Merck vaccines. The updated 2023-2024 SARS-CoV-2 virus (COVID-19) mRNA vaccine produced by Pfizer-BioNTech and the one produced by Moderna are recommended for people 6 months and older. • If vaccines were moved to another unit please provide 3 days stable temps in range before moving vaccines back into unit. 6372). , Defining Shelf-Life for the COVID-19 Vaccine EUA, AAPS Vaccine Stability Workshop, March 24-25, 2021 The panel also discussed additional approaches, including a suite of orthogonal analytical techniques such as SDS-PAGE, RP-HPLC, MALS, LC-MS, etc. For more information regarding digital data logger training go to SCIAPPS Vaccine Manufacturer’s Quality Control Phone Numbers Sanofi Pasteur 800‐822‐2463 ActHib® Sanofi Pasteur Temperature Excursion Calculator Enter Start Temperature (°C): Enter End Temperature (°C): Duration of Excursion (hours): Check Excursion Here’s a comprehensive table providing all you need to know about Sanofi Pasteur Temperature Excursion, including its definition, recommended storage conditions, effects of temperature Your practice cannot afford to let vaccines go to waste. To successfully carry out global immunization programs, ensuring the stability of vaccines is crucial. The first 3 doses were administered to infants at 2, 4, and 6 months of age and the fourth dose was administered to children at 12 through 15 months of age. Covid-19 : 866-663-3762 Moderna Stability Calculator Novavax . This can slow down your immunization program and put your patients at risk (see below for a simple (Ebola Zaire Vaccine, Live) GARDASIL ® 9 (Human Papillomavirus 9-valent Vaccine, Recombinant) M-M-R ® II (Measles, Mumps, and Rubella Virus Vaccine Live) PedvaxHIB ® [Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate)] PNEUMOVAX ® 23 (Pneumococcal Vaccine Polyvalent) ProQuad ® (Measles, Mumps, Rubella and Varicella Virus Any changes in process, formulation, shipping, and/or storage can cause physical and/or chemical changes in a product. Vaccine shelf life prediction is a essential operate facilitated by instruments just like the Merck Vaccine Stability Calculator. Catch-up vaccination schedule for children 7 months to less than 18 years of age Wait for advice and further instructions from the Immunization Division regarding the excursion. 3, 17) • GARDASIL 9 has not been demonstrated to provide protection against disease caused by: If you have questions about the condition of the vaccine at the time of delivery, you should immediately place vaccine in recommended storage and call the Merck Vaccine Customer Center at 877. (5. PMID: The management of temperature levels in vaccine storage units and vaccine supply systems is an important issue for maintaining viable supplies of vaccine for immunization programs [1–3]. Once Covid-19 vaccines become available, 5–10 billion vaccine doses should be globally distributed, stored and administered. The provision of vaccines was based on the UK Department of Health recommendation and stock availability at vaccination hubs. Vaccine Stability Calculator ☐Abrysvo ☐Prevnar 20 ☐Penbraya ☐Trumemba ☐Viable ☐Non-viable: Sanofi Pasteur 800-822-2463. com) Pfizer 1-800-438-1985 Stability Tool: Temperature Stability %PDF-1. Registered Office: 23 Rochester Park Singapore 139234 Merck (800) 672-6372 Press: 1, 2, 2 ; Moderna (866) 663-3762 ; Novavax (844) 668-2829 ; Pfizer (800) 438-1985 Seqirus (855) 358-8966 Press:1 ; Providers may also utilize the online vaccine stability calculators to determine whether the . However, these advantages come with challenges such as stability during manufacturing and sizing the most appropriate Merck The updated 2023-2024 SARS-CoV-2 virus (COVID-19) mRNA vaccine produced by Pfizer-BioNTech and the one produced by Moderna are recommended for people 6 months and older. S. Rotate stock so If you do not see your medicine, or have a question that cannot be answered by using this tool, please use the search functionality on www. Merck 1-800-672-6372 Sanofi Pasteur 1-800-822-2463 Use this tool to calculate the stability of any GSK vaccine. com Pfizer and BioNTech Submit COVID-19 Vaccine Stability Data at Standard Freezer Temperature to the U. Skip to main content . Stability-indicating stability of a vaccine. (NYSE: PFE) and BioNTech SE (Nasdaq: BNTX) today announced the submission of new data to the U. During clinical trials, some children received varicella vaccine (Oka/Merck) intramuscularly resulting in seroconversion rates similar to those in children who received the vaccine by the subcutaneous route. gov to file a report, or call 1-800-822-7967. 5ml pre-filled syringes (GlaxoSmithKline UK Ltd) Excursion Case The stability data contained in the tables represents information from product monographs or published stability studies that is available in the public domain. vaers. Merck Vaccine Customer Center . MERCK (877. Contact Correct. This tool provides information based on a single occurrence of a temporary temperature excursion and does not consider other factors that may affect product stability such as light exposure or humidity. Staff must immediately quarantine affected vaccines and The manufacturer’s stability representative will supply you with a case number and a determination of the vaccine’s viability. 2; and in 1 of 385 [0. Do not use or administer any vaccines until instructed by Immunization Division. Disposal 1. 472. Abstract. . 6 DOSAGE FORMS, STRENGTHS, COMPOSITION AND PACKAGING . 2180. Visit www. In this context, two important issues are critical, namely: (i) predicting vaccine stability and (ii) The Stability Community of the American Association of Pharmaceutical Scientists (AAPS) held a virtual workshop on "Vaccine Stability Considerations to Enable Rapid Development and Deployment", on March 24-25, 2021. This process involves complex calculations based on various factors influencing vaccine stability. Moderna Fellowship; Moderna Foundation; Stability of vaccine: the ability of a vaccine to retain its physical, chemical, biological, biopharmaceutical and microbiological properties within specified limits to assure clinical performance throughout its shelf-life. PNEUMOVAX® 23 (pneumococcal vaccine polyvalent) Sterile, Liquid Vaccine for Intramuscular or Subcutaneous Injection Initial U. See what to do with vials of the Moderna COVID-19 Vaccine that may have experienced a temperature excursion prior to administering. Although this variety could have potentially introduced different immunogenicity, nearly all participants received an mRNA vaccine that contained the antigen sequence homology to the ancestral B. mRNA technologies show strong potential to continue to unlock RNA medicines as a broader set of vaccines and therapies with significant advantages in terms of time-to-market, efficacy, and flexibility. Menu. Yajie Zhang, Ph. Merck Access Program Information about insurance coverage and financial assistance options for eligible patients. 829. Adjuvants: Substances that are intended to enhance relevant immune response and subsequent clinical efficacy of the vaccine. Infants and children who have begun immunisation with another pneumococcal conjugate vaccine may switch to Vaxneuvance at any point in the schedule (see section 5. Clinical safety of refrigerator-stable varicella vaccine (Oka/Merck) (n=635) was compared with that of the licensed frozen formulation of varicella vaccine (Oka/Merck) (n=323) for 42 days VARIVAX® III (varicella virus vaccine, live, attenuated [Oka/Merck]) is recommended for intramuscular or subcutaneous administration. Sanofi Pasteur: 1-800-822-2463: GlaxoSmithKline: 1-888-825-5249: Pfizer: 1-800-438-1985: Seqirus : 1-855- 358-8966: This can prevent vaccine waste and the potential need to revaccinate patients. NEW YORK and MAINZ, GERMANY, February 19, 2021 — Pfizer Inc. Merck Stability Calculator: Moderna: 1-866-663-3762: Moderna Stability Calculator: Pfizer: 1-800 ProQuad® (Measles, Mumps, Rubella and Varicella Virus Vaccine Live) Page 7 of 46. 800--6726372 Option 2: Vaccine Stability Calculator ☐Gardasil ☐MMR II ☐PedvaxHIB ☐Vaxneuvance ☐Zostavax ☐Viable ☐Non-viable: Pfizer/Wyeth 800-438-1985 Option 3. Transmission of vaccine virus strains from vaccinees to non-vaccinated contacts has been Stability evaluation supporting vaccine licensure includes studies of bulk intermediates as well as final container product. vaccine, use the sterile diluent vial supplied with VARIVAX. , Inc. This is an issue that affects immunization programs in the United States [] and those around the world [5, 6]. Contacting Manufacturers for Vaccine Stability Determination Pages 12–14 3. Infectious Diseases and Vaccines Discovery, Merck Research Laboratories, Merck & Co. Protect from light. , West Point, Pennsylvania 19486. The decision about when to administer an intramuscular vaccine, including VAXELIS, to an infant born prematurely Vaccine drug product thermal stability often depends on formulation input factors and how they interact. Access the Stability Calculator. com) Stability Tool: Merck Vaccine Temperature Stability Calculator (merckmedicalportal. To help ensure the traceability of vaccines for patient immunization record-keeping as well as safety monitoring, health professionals should record the time and date of administration, quantity of Vaccine shelf life prediction is a critical function facilitated by tools like the Merck Vaccine Stability Calculator. Vaccine shelf life prediction. Get prescribing information and patient resources. What temperature was the product exposed to? For vaccines that require If you have questions about the condition of the vaccine at the time of delivery, you should immediately place the vaccine in the recommended storage and call the Merck Vaccine Customer Care Center at 877. “We’re committed to advancing and mobilizing our scientific research and expertise, supply capacity and strong external collaborations to build awareness, trust, access and acceptance of vaccines prevent vaccine waste and the potential need to revaccinate patients. Long-term and accelerated studies are performed to support shelf life and to determine release limits for the vaccine. You are encouraged to report vaccine adverse reactions to the US Department of Health and Human Services. loginlink. Coronavirus (COVID-19) vaccines are in short supply. Vaccine shelf life is best determined utilizing a formal Please use the link below to request data logger, vaccine storage unit, or temperature excursion support from the Montana Immunization Program. vaccine is still viable after an Excursion. BCG Vaccine U. GSK Response Center: 1-888-593-5977. This page contains resources to help providers understand and follow proper vaccine storage and handling practices. Logging an Excursion Event Pages 2–11 2. 1 Rotate stock so that the shortest-dated vaccine is used first. Merck @ Co, Inc. When extended stability data is not available on the fridge tool, (Merck Serono Ltd) Information as per product licence Infanrix-IPV + Hib vaccine powder and suspension for suspension for injection 0. Whe The site is made available by Merck’s Global Medical and Scientific Affairs organization, a part of Merck Research Laboratories, and is provided as a scientific resource for informational, non-promotional purposes. D. D The vaccine manufacturer does not recommend transporting varicella-containing vaccines (varicella, MMRV). Consult the vaccine manufacturer and/or your state or local immunization program for guidance. 6372) In clinical trials in children, VAQTA was concomitantly administered with one or more of the following US-licensed vaccines: Measles, Mumps, and Rubella Virus Vaccine, Live; Varicella Vaccine, Live; Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine, Adsorbed; Measles, Mumps, Rubella, and Varicella Vaccine, Live; Pneumococcal 7-valent Conjugate Stability guidelines Written Standards Vaccines. VXWCNT190003 March 2019. Document all details of the event; VFC providers must n otify their LHD and provide temperature excursion data if VFC stock is involved • Merck: 1-800-672-6372 • Pfizer: 1-800-438-1985 Sanofi Pasteur: 1 -800 822 2463 or www. The table below lists the links to the online vaccine Merck @ Co, Inc. For a Merck product (other than vaccines): submit the stability inquiry by contacting us at: Website: www. , Regeneron. com) Moderna 1-866-663-3762 Stability Tool: Storage & temperature excursion for Moderna COVID-19 vaccine (modernamedinfo. Title: Handling a Temperature Excursion - Vaccine Storage Unit Merck 1-800-672-6372 Website Tool: Vaccine Reporting Form (merck. 1 Ensure that the refrigerator is plugged into an outlet in a protected area where it Contents Part Page Number 1. Merck 1-800-672-6372 Sanofi Pasteur 1-800-822-2463 At Sanofi, find our vaccines, including influenza, meningitis, pertussis, and more. Simply select the product and enter the temperature and total time data required. Excerpt from Scholten, A. Approval: 2021 To report SUSPECTED ADVERSE REACTIONS, contact Merck Sharp & Dohme LLCat 1 -8778884231 or VAERS at 1 8008227967 or www. The workshop included distinguished speakers and panelists from across the industry, Find the expiration date for any vial of Moderna COVID-19 Vaccine through the LOT number on the vial. To reconstitute the vaccine, withdraw the entire volume of the supplied sterile diluent from the vial and slowly inject into the lyophilized vaccine vial. Simply select from the required information below. EUA label update would enable the vaccine to be stored at -25°C to -15°C (-13°F to 5°F) for a total of two weeks If approved, new storage option could offer • Vaccination with GARDASIL 9 does not eliminate the necessity for vaccine recipients to undergo screening for cervical, vulvar, vaginal, anal, oropharyngeal and other head and neck cancers as recommended by a health care provider. Products. If you discover expired vaccine, remove it from the refrigerator or freezer so that it is not inadvertently given to a patient. Find the dosing schedule for VAQTA® (Hepatitis A Vaccine, Inactivated) and review the flexible dosing window for VAQTA. This is particularly relevant for vaccines, with numerous vaccines strictly requiring cold storage to remain stable. Contact us. This original PBS formulation of this vaccine requires ultra-cold temperatures of between −90 °C and −60 °C, commonly −80 °C for shipment and longer term storage for up to 6 months, cf. 7 %âãÏÓ 146 0 obj > endobj 174 0 obj >/Filter/FlateDecode/ID[1E9C15CEA2A731498EBF4561D6A9A63B>4DFD99E62C01154DA1FFEAD3CAD9BC09>]/Index[146 84]/Info 145 0 R ©2025 GSK group of companies or its licensor. com Study 8 was a pivotal, double-blind, active comparator-controlled study in which participants were randomized to receive VAXNEUVANCE (N=860) or PCV13 (N=860) in a 4-dose series. CAPVAXIVE™ (Pneumococcal 21-valent Conjugate Vaccine) ERVEBO ® (Ebola Zaire Vaccine, Live); GARDASIL ® 9 (Human Papillomavirus 9-valent Vaccine, Recombinant); M-M-R ® II (Measles, Mumps, and Rubella Virus Vaccine Live); PedvaxHIB ® [Haemophilus b Conjugate Vaccine (Meningococcal Protein If you have questions about the condition of the vaccine at the time of delivery, you should immediately place vaccine in recommended storage and call the Merck Vaccine Customer Center at 877. Vaccine Stability Yet, vaccine-preventable diseases and outbreaks persist in some contexts — due largely to low vaccination rates often resulting from vaccine hesitancy or challenges with access. These products are designed to enhance the well-being and improve the health of animals. Vaccine stability, which is reflected by monitoring its critical quality attributes, can be affected by cell culture media composition (nutrients and Merck & Co. Transmission of vaccine virus was not evaluated in phase 3 studies. Viewing and Editing an Excursion Event vaccine containing tetanus toxoid, the risk for Guillain-Barré syndrome may be increased following VAXELIS. , and how they have been applied for Stability modeling for vaccines represents a key resource to predict stability based on accelerated stability studies; nevertheless, this approach is not fully exploited for these kinds of products. Menu Close. com Use Amgen temperature stability calculator to resolve stability related questions for Amgen products. sanofiusmedicalinformation. Close. 3%, 95% CI (<0. Table 2 [18,20,37,38]. 6 VACCINESTORAGEANANINGTOOIT˜˜ WORKSHEET: Vaccine Storage and Handling SOPs RESOURCES PACKING MATERIAL SUPPLIERS CONTACT LIST Emergency Resources Company Name Contact Person Name/Title Telephone Numbers home/cell/other E-mail Address The Temperature Stability Calculator is designed to help address stability questions following a potential storage temperature excursion after a Genentech product has arrived at the healthcare facility or pharmacy. It saves the cost of replacing valuable vaccines and makes sure viable vaccine is available to protect kids from vaccine-preventable diseases. If the manufacturer offers an on-line stability calculator, you may use those, include a printed copy of the results with your completed incident report. co. When storing COVID-19 vaccines in your practice, you can use the logs below to track, check, and record daily temperatures. P. Guidelines on stability evaluation of vaccines, TRS No 962, Annex 3 Janssen Shelf-life Model used for COVID-19 Vaccine. Food and Drug Administration (FDA) demonstrating the stability of their COVID-19 vaccine when stored at -25°C to -15°C (-13°F to 5°F), temperatures more commonly found in Vaccine shelf life prediction is a critical function facilitated by tools like the Merck Vaccine Stability Calculator. If your inventory falls out of the required vaccine storage temperatures, vaccines can become damaged, ineffective, and unsafe to use. All three vaccines must be protected from light, which might inactivate the vaccine viruses, the vaccines have different storage requirements. Refrigerator Vaccine Storage Temperature Logs (Jan 2021) l Due to their thermosensitivity, most vaccines must be kept refrigerated from production to use. Vaccine Service Center: 1-866-475-8222. GlaxoSmithKline Pte Ltd, Registered in Singapore No 198102938K. Recent studies have suggested that cold-chain lapses were potential causes of vaccine Label exposed vaccine “DO NOT USE”. Simply select the product and provide time and temperature information. hhs. Approval: 1983 To report SUSPECTED ADVERSE REACTIONS, contact Merck Sharp & Dohme LLC at 1-877-888-4231 or VAERS at 1-800-822-7967 or www. The sterile diluent does not contain preservatives or other antiviral substances which might inactivate the vaccine virus. Vaccine Manufacturer Contact Information Vaccines stability of a vaccine. Clinical trials Learn about our clinical trials and find available studies. CS249275-BG. Prior vaccination with another pneumococcal conjugate vaccine. Frozen Vaccines Temperature Monitoring (Feb 2018) Fahrenheit (F) | Celsius (C) Temperature Logs for COVID-19 Vaccines. Document the details of the temperature excursion including the: • Date, time, Merck 800-672-6372 Moderna 866-663-3762 Novavax 855-239-9174 Pfizer 800-438-1985 Sanofi Pasteur 800-822-2463 If you have questions about the condition of the vaccine at the time of delivery, you should immediately place vaccine in recommended storage and call the Merck Vaccine Customer Center at 877. Vaccine Stability The “Temperature Stability Calculator” will conduct the assessment promptly, and you will have the option to download the results for this specific evaluation directly from the portal. mupmj rqxk sojmhd fsajea wmtpd bkjmuy sascmmc gfrwbja fzhol kmivf lzuu mwipvx gzwtoqvz snjdb mkiunac